HEAT-NET Frontiers in Neurodegeneration: from bench to bedside

New location:
ZHG Lecture hall 008
Platz der Göttinger Sieben 5, 37073 Göttingen

Preliminary program – HEAT-net Meeting –  September 6-8 (Mon-Wed), 2021

Start
13:00 Arrival
13:45-14.00 Welcome: Tiago Outeiro, Christine von Arnim, Martin Ingelsson, Alberto Lleó
14:00-14:10 Dean of University Medical Center Göttingen: Prof. Wolfgang Brück
Session 1 Synaptic dysfunction: where it all starts
14:15 – 14:30 Tiago Outeiro: Alpha-Synuclein at the synapse: dangerous interactions – In Person
14:30 – 14:45 Tara Spires: Synapse degeneration and resilience in ageing and neurodegeneration – the
role of microglia in synaptic degeneration in Alzheimer’s disease – In Person
14:45 – 15:00 Christine Stadelmann-Nessler: Neurodegenerative aspects of multiple sclerosis – In Person

15:00-15:30 Coffee break

Session 2 Preclinical models of neurodegeneration
15:30 – 15:45 Annakaisa Haapasalo: Effects of the C9orf72 repeat expansion in preclinical models of frontotemporal lobar degeneration – Via Zoom
15:45 – 16:00 Monica Garcia-Alloza: Alzheimer´s disease and diabetes mellitus: models and translational implications – In Person

16:00-16:30 break

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Session 3 Keynote lecture – moderator: Tiago Outeiro
16:30 – 17:00 Brian Bacskai: Imaging the pathophysiology of animal models of Alzheimer’s disease – Via Zoom
17:00 – 17:15 Discussion
17:15 Welcome reception

19:30 Speaker’s dinner

8:30-9:00 Coffee break

Session 4 Brief talks by junior investigators (In Person)
9:00-10:15 Moderators: Anish Behere, Annekatrin König
Brief talks by junior investigators: Anish Behere, Annekatrin König, Julia Schulze, Maria Vargas Soria, Silvia Zampar

10:15-10:30 Coffee break

10:30-10:45                Alternative options in science
Lena Oesterlin-Meret: Life Science Factory

Session 5 Brief talks by junior investigators (Via Zoom)
10:45-12:00 Moderators: Maria Vargas Soria, Silvia Zampar
Brief talks by junior investigators: Viviana Brembati, André Felipe Vieira da Conceição, Angel del Marco, Dorit Hoffmann, Agnieska Molisak, Paula Ferrer Raventós, Sonia Sabaté Soler, Marta Querol Vilaseca

12:00-14:00 Lunch

Session 6 Genetics & biomarkers of neurodegeneration in Parkinson‘s disease
14:00-14:15 Christina Lill: The role of micro-RNAs in Alzheimer’s disease and Parkinson‘s disease – Via Zoom
14:15-14:30 Lars Bertram: Epigenome-wide association study in Alzheimer’s disease using DNA methylation in human brain samples – Via Zoom
14:30-15:00 Discussion

15:00-15:40 Coffee break and Posters – In Person and via Zoom

Session 7 The heat is on: Inflammation in neurodegeneration
15:40-15:55 Christine von Arnim: Neuropsychiatric symptoms, stress and inflammation in dementia – In Person
15:55-16:10 Karin Danzer: The role of monocytes in Parkinson’s disease and amyotrophic lateral sclerosis – Via Zoom
16:10-16:25 Mikko Hiltunen: Microglial molecular regulatory networks in neurodegeneration – Via Zoom

16:25-16:30 Break

Session 8 Keynote lectures – moderator: Christine von Arnim
16:30-17:00 Bradley T. Hyman: How heterogeneous is Alzheimer’s disease clinically and biologically? – Via Zoom
17:00-17:30 Rudy Tanzi: The innate immune hypothesis of Alzheimer’s Disease – Via Zoom
17:30-18:00 Xandra Breakefield: Any parallels between neurodegeneration and brain tumors? – Via Zoom
18:00-18:20 Discussion
[INTERNAL *18:15-19:00 Internal HEAT-NET members with mentors*]

19:30 Speakers‘ dinner

8:30-9:00 Coffee

Session 9 Biomarkers in Alzheimer’s disease and related disorders
9:00-9:15 Alberto Lleó: Cerebrospinal fluid biomarkers in early Alzheimer’s disease – In Person
9:15-9:30 Jens Wiltfang: Current and emerging molecular biomarkers for the blood-based early diagnostics of Alzheimer’s disease – In Person
9:30-9:45 Inga Zerr: Biomarker research to understand molecular heterogeneity in neurodegenerative diseases – Via Zoom
9:45-10:00 Markus Otto: Fluid biomarkers in frontotemporal dementia and amyotrophic lateral sclerosis – In Person
Session 10 Keynote lecture. Moderator: Martin Ingelsson
10:00-10:30 Lars Lannfelt: Targeting soluble aggregated Aβ with lecanemab (BAN2401) – from mutation to potential therapy for Alzheimer’s disease – Via Zoom
10:30-10:45 Discussion

10:45-11:15 Coffee break

Session 11 Biomarkers and Treatmeant for Neurodegeneration: Present and Future
11:15 – 11:30 Brit Mollenhauer: Emerging biomarkers in Parkison’s disease – In Person
11:30 – 11:45 Andre Fischer: RNA and the epigenome as targets for stratified therapies in neurodegenerative diseases – In Person
11:45 – 12:00 Martin Ingelsson: CRISPR/Cas9 as a novel gene therapy tool for neurodegenerative diseases – In Person
Session 12 Poster Session
12.00-13:00 Poster Session – In Person and via Zoom
Closing Session
13:00 Closing and end of meeting: Christine von Arnim, Martin Ingelsson, Alberto Lleó, Tiago Outeiro
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