My research interests are in the genetic background and mechanisms of neurodegenerative diseases, particularly frontotemporal dementia (FTD) and Alzheimer’s disease. We use cellular and animal models and patient-derived fibroblasts, induced pluripotent stem cells to produce different brain cells, and brain, blood, and cerebrospinal fluid samples and different molecular, cell biological and biochemical methods. Our aim is to identify novel disease-associated factors, assess their mechanistic role in disease pathogenesis, and correlate their changes to the clinical features of patients. Currently, I am especially interested in potential synaptic dysfunction, contribution of microglia and inflammation, and defects in autophagy and mitochondrial function in FTD.
Ongoing HEAT-NET collaboration
Mikko Hiltunen: Ongoing research collaboration and co-authoring in 27 publications during last 5 ye
Martin Ingelsson: Co-authoring in 3 publications during last 5 years
Alberto Lleo: Co-authoring in 3 publications during last 5 years. Currently co-guest editing a special research theme in Frontiers in Neuroscience on “Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis: Genetics, Clinical and Pathological Features, and Disease Mechanisms”,https://www.frontiersin.org/research-topics/8606/frontotemporal-lobar-degeneration-and-amyotrophic-lateral-sclerosis-genetics-clinical-and-pathologic