Martin Ingelsson has a long-standing collaboration with Tiago Outeiro on studies of molecular aspects in Parkinson’s disease and has previously worked together with Jochen Klucken in the same field of research. In a new project, he is working together with Alberto Lleo and Christine von Arnim to discover novel cerebrospinal fluid-based biomarkers for neuroinflammation in Alzheimer’s disease. Together with Mikko Hiltunen he participates in a European initiative aimed at elucidating adiditional genetic factors underlying Alzheimer’s disease and he has previously collaborated with Lars Bertram on the same topic. With Monica Garcia-Alloza and Tara Spires-Jones he is investigating molecular brain features of patients with a co-morbidity of Alzheimer’s disease and diabetes mellitus. Furthermore, with Tara Spires Jones he is also characterizing synaptic pathology in a newly generated mouse model of Alzheimer’s disease.
List of Heat-Net collaborative publications with at least 1 member of the consortium (from other Heat-Net group) from the last 5 years.
Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.
Gustafsson G, Lööv C, Persson E, Lázaro DF, Takeda S, Bergström J, Erlandsson A, Sehlin D, Balaj L, György B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M.
Cell Mol Neurobiol. 2018 Nov;38(8):1539-1550. doi: 10.1007/s10571-018-0622-5. Epub 2018 Oct 4.
Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.
Gustafsson G, Eriksson F, Möller C, da Fonseca TL, Outeiro TF, Lannfelt L, Bergström J, Ingelsson M.
Cell Mol Neurobiol. 2017 Jan;37(1):121-131. doi: 10.1007/s10571-016-0352-5. Epub 2016 Mar 10.
Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.
Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2013 Dec;20(4):233-44. doi: 10.3109/13506129.2013.835726. Epub 2013 Sep 20.
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF.
J Neurosci. 2012 Aug 22;32(34):11750-62.
Antibodies against alpha-synuclein reduce oligomerization in living cells.
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M.
PLoS One. 2011;6(10):e27230. doi: 10.1371/journal.pone.0027230. Epub 2011 Oct 31.