About Christine

Dr. Christine von Arnim is a geriatrician and neurologist combining basic and clinical research on cognitive dysfunction and dementia. Her main areas of clincial research are the diagnosis and treatment of neurodegenerative dementias including CSF biomarkers, and clinical cardio-neuro-geriatrics. This includes non-drug interventions like cognitive training and physical exercise programs and intervention for preventing delirium. Her basic research focuses on the cell biology of Alzheimer’s disease including APP function and metabolism and mitochondria.

Ongoing HEAT-NET collaboration

Increased cerebrospinal fluid levels of neuroinflammatory markers at an early stage of Alzheimer’s disease: with Martin Ingelsson and Alberto Lleo

  • Different Inflammatory Signatures in Alzheimer’s Disease and Frontotemporal Dementia Cerebrospinal Fluid.
    Boström G, Freyhult E, Virhammar J, Alcolea D, Tumani H, Otto M, Brundin RM, Kilander L, Löwenmark M, Giedraitis V, Lleó A, von Arnim CAF, Kultima K, Ingelsson M.
    J Alzheimers Dis. 2021;81(2):629-640. doi: 10.3233/JAD-201565.

  • Data driven diagnostic classification in Alzheimer’s disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species.
    Oliveira F, Leuzy A, Castelhano J, Chiotis K, Hasselbalch SG, Rinne J, Mendonça A, Otto M, Lleó A, Santana I, Johansson J, Anderl-Straub S, Arnim C, Beer A, Blesa R, Fortea J, Sanna-Kaisa H, Portelius E, Pannee J, Zetterberg H, Blennow K, Moreira AP, Abrunhosa A, Nordberg A, Castelo-Branco M.
    Neuroimage Clin. 2018 Aug 19;20:603-610. doi: 10.1016/j.nicl.2018.08.023. eCollection 2018.

  • Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
    Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, Swingler R, Chandran S, Gillingwater TH, Abrahams S, Spires-Jones TL.
    Acta Neuropathol. 2018 Feb;135(2):213-226. doi: 10.1007/s00401-017-1797-4. Epub 2017 Dec 22.

  • Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress.
    Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken J.
    Sci Rep. 2017 Feb 22;7:42942. doi: 10.1038/srep42942.

  • Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.
    Leuzy A, Chiotis K, Hasselbalch SG, Rinne JO, de Mendonça A, Otto M, Lleó A, Castelo-Branco M, Santana I, Johansson J, Anderl-Straub S, von Arnim CA, Beer A, Blesa R, Fortea J, Herukka SK, Portelius E, Pannee J, Zetterberg H, Blennow K, Nordberg A.
    Brain. 2016 Sep;139(Pt 9):2540-53. doi: 10.1093/brain/aww160. Epub 2016 Jul 7.

  • The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease.
    Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E; SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CAF, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L.
    Alzheimers Dement. 2015 Dec;11(12):1407-1416. doi: 10.1016/j.jalz.2014.12.009. Epub 2015 Apr 30.