About Lars

Lars is head of the “Lübeck Interdisciplinary Platform for Genome Analytics” (LIGA) which is part of University of Lübeck’s Medical Faculty (“Sektion Medizin”). The overarching aim of LIGA is to improve our understanding of the genetic and epigenetic foundations of genetically complex human traits and diseases, in particular those related to aging. To this end, our group uses state-of-the-art high-throughput genome technologies in human DNA and RNA samples recruited within the auspices of a number of different national and international collaborative projects, including EMIF-AD, LifeBrain, MiRNetAD, and BASE-II.

Ongoing HEAT-NET collaboration

  • With Alberto Lleo in the European Medical Information Framework – Alzheimer’s disease (EMIF-AD) consortium project

  • With Christine von Arnim (on the genetics of AD) and Christina Lill (on the genetics of PD)

List of Heat-Net collaborative publications with at least 1 member of the consortium (from other Heat-Net group) from the last 5 years.

  • The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.
    Bos I, Vos S, Vandenberghe R, Scheltens P, Engelborghs S, Frisoni G, Molinuevo JL, Wallin A, Lleó A, Popp J, Martinez-Lage P, Baird A, Dobson R, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Bertram L, Ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Visser PJ.
    Alzheimers Res Ther. 2018 Jul 6;10(1):64. doi: 10.1186/s13195-018-0396-5.

  • Elucidation of the BACE1 regulating factor GGA3 in Alzheimer’s disease.
    Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M.
    J Alzheimers Dis. 2013;37(1):217-32. doi: 10.3233/JAD-130104.

  • Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.
    Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M.
    Biochemistry. 2013 Jun 4;52(22):3899-912. doi: 10.1021/bi400138p. Epub 2013 May 21.

  • The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease.
    Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E; SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CAF, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L.
    Alzheimers Dement. 2015 Dec;11(12):1407-1416. doi: 10.1016/j.jalz.2014.12.009. Epub 2015 Apr 30.